|
|
|
|
( Yoshiko Sakuma ) - Fukuoka University School of Nursing
( Kumi Arita ) - Fukuoka University School of Nursing
( Ryoko Baba ) - University of Occupational and Environmental Health School of Medicine Department of Anatomy
( Nana Kumagai ) - Nakamura Gakuen University Graduate School of Health and Nutrition Sciences
( Mamoru Fujita ) - Nakamura Gakuen University Graduate School of Health and Nutrition Sciences
|
|
Abstract
|
|
|
|
|
Purpose: We investigated the effects of breast-feeding and supplementary-feeding on jejunal villi morphology and jejunal absorptive capacity at the early neonatal stage.
Methods: Newborn Wistar rats were separated from their mothers immediately after birth and allocated to a breast-fed, mixed-fed (breast-feeding and formula-feeding), or formula-fed group. Rats were fed accordingly for 3 days. We then investigated the morphology of jejunal villi and the mechanism of macromolecular uptake by absorptive cells in each group. Horseradish peroxidase (HRP) was used as a representative macromolecule.
Results: After three days of feeding, jejunal villi of breast-fed rats were longest, followed by the mixed-fed, and then formula-fed groups. Additionally, HRP underwent transcytosis from the apical membrane to the basolateral membrane of absorptive cells in the breast-fed group. HRP did not undergo transcytosis in either the formula-fed or mixed-fed rat jejuna.
Conclusion: Our findings suggest that supplementary feeding affects normal villus development and impairs endocytosis and transcytosis in early neonatal stage jejunal absorptive cells.
|
|
|
KeyWords
|
|
Breastfeeding , Newborn , Jejunum , Transcytosis
|
|
|
원문 및 링크아웃 정보
|
|
|
|
|
|
등재저널 정보
|
|
|
|
|
|
|
|